The Argentina international signed a four-year contract with the Serie A champions on Tuesday, worth £6.3m per season.
The £75.3m fee, an Italian football record, is also the third most expensive transfer of all-time, behind only Cristiano Ronaldo and Gareth Bale's moves to Real Madrid.
Let's take a look at where Higuain fits into our most expensive XI...
We start in goal with Juventus and Italy legend Gianluigi Buffon, who moved from Parma to Juventus for £32.6m in 2001 and remains the most expensive goalkeeper 15 years later.
His defence is marshalled by David Luiz, who left Chelsea for Paris Saint-Germain in a £40m deal, and Rio Ferdinand, who crossed the Pennines for £29.1m to join Manchester United from Leeds United in 2002.
The full-back positions are occupied by Lilian Thuram and Luke Shaw. Former France international Thuram left Parma for Juve alongside team-mate Buffon, while Shaw became the most expensive left-back ever when he moved from Southampton to Man Utd two years ago.
In midfield, an embarrassment of attacking riches means we've gotZinedine Zidane and James Rodriguez, two forward-thinking players, slightly further back.
Zidane became one of the original Galacticos upon joining Real from Juve for £47.2m in 2001, having helped France to a World Cup and European Championship double.
International excellence also earned James a move to the Bernabeu 13 years later, having starred at the 2014 World Cup with Colombia. He swapped Monaco for the Spanish capital for £63m, making him the third-most expensive player in Real's history.
Our 4-2-3-1 formation comes into its own up front, allowing us to play three forwards behind a main striker.
Gareth Bale is guaranteed a spot having become the most expensive player in football history when he moved from Tottenham to Real for £85.3m in 2013, eclipsing Cristiano Ronaldo's previous world-record mark.
The Portugal international moved from Man Utd to Real for £80m, whileNeymar is the third attacker thanks to his £73.7m move from Santos to Barcelona in 2013.
On Monday, the central striker position would have been occupied by Luis Suarez of Barcelona, but Higuain's record-breaking move earns the former Napoli man the leading place.
His £75.3m transfer to Juve is more than £10m more than Barca paid Liverpool for Suarez two summers ago.
Top 10 most expensive transfers
- Gareth Bale
Tottenham to Real Madrid - £85.3m - Cristiano Ronaldo
Man Utd to Real Madrid - £80m - Gonzalo Higuain
Napoli to Juventus - £75.3m - Neymar
Santos to Barcelona - £73.7m - Luis Suarez
Liverpool to Barcelona - £65m - James Rodriguez
Monaco to Real Madrid - £63m - Angel Di Maria
Real Madrid to Man Utd - £59.7m - Kaka
AC Milan to Real Madrid - £59m - Edinson Cavani
Napoli to PSG - £55m - Kevin De Bruyne
Wolfsburg to Man City - £54.5m
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